In aging patients, distribution of drugs may be lessened because of a decline in total body water and lean body mass, warranting the use of decreased dosing. Which drugs are distributed into body water or lean muscle mass and may lead to increased effects
effects and possible toxicity for the aging patient? (Select all that apply.)
a.
Digoxin (Lanoxin)
b.
Gentamicin (Garamycin)
c.
Meperidine (Demerol)
d.
Acetaminophen (Tylenol)
e.
Ibuprofen (Motrin)
ANS: A, B, C
Drugs that are distributed into body water or lean body mass include digoxin, cimetidine, lithium, gentamicin, meperidine, phenytoin, and theophylline.
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