Which groups of antineoplastic medications have been extracted from plants?(Select all that apply.)
1. Vinca alkaloids
2. Topoisomerase inhibitors
3. Taxanes
4. Alkylating agents
5. Antimetabolite agents
1, 2, 3
Rationale 1: Vinca alkaloids are derived from the periwinkle plant.
Rationale 2: Topoisomerase inhibitors block enzyme topoisomerase isolated from the May apple long plant.
Rationale 3: Taxanes are isolated from the Pacific yew, an evergreen found throughout the western United States.
Rationale 4: Alkylating agents have not been extracted fromplants.
Rationale 5:Antimetabolite agents chemically resemble essential building blocks of the cell. They are not extracted from plants.
Global Rationale: Chemicals with antineoplastic activity have been isolated from a number of plants. These include vinca alkaloids, topoisomerase inhibitors, and taxanes.
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