What is the mechanism by which leucovorin reduces the toxicity of methotrexate?
A. Leucovorin increases intracellular tetrahydrofolate levels
B. Leucovorin decreases polyglutamylation of methotrexate in cells
C. Leucovorin downregulates dihydrofolate reductase levels in cells
D. Leucovorin upregulates thymidylate synthase levels in cells
E. None of the above
Ans: A. Leucovorin increases intracellular tetrahydrofolate levels
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