A patient who is taking acetaminophen for pain wants to know why it does not cause gastrointestinal upset, as do other over-the-counter pain medications. The nurse will explain that this is most likely because of which property of acetaminophen?
a. It does not inhibit cyclooxygenase.
b. It has minimal effects at peripheral sites.
c. It is more similar to opioids than to nonsteroidal anti-inflammatory drugs (NSAIDs).
d. It is selective for cyclooxygenase-2.
ANS: B
The differences between the effects of acetaminophen and aspirin are thought to result from selective inhibition of cyclooxygenase; acetaminophen has only minimal effects on cyclooxygenase at peripheral sites, which may explain why acetaminophen does not have adverse GI, renal, and antiplatelet effects. Acetaminophen is a selective COX inhibitor. It is not more similar to opioids than NSAIDs. It is not selective for COX-2.
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