What is the drug of choice for the pharmacotherapy of Paget disease?
1. Bisphosphonates
2. Selective estrogen-receptor modulators (SERMs)
3. Hormone replacement therapy (HRT)
4. NSAIDs
1
Rationale 1: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
Rationale 2: Selective estrogen-receptor modulators (SERMs) are used in the treatment of osteoporosis.
Rationale 3: Hormone replacement therapy (HT) is used for menopause.
Rationale 4: NSAIDs areused for a variety of inflammatory conditions.
Global Rationale: Bisphosphonates are drugs of choice for the pharmacotherapy of Paget disease. Therapy is usually cyclic: Bisphosphonates are administered until serum alkaline phosphatase levels return to normal; then a drug-free period of several months follows. When serum alkaline phosphatase levels become elevated, therapy is begun again.
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