After reviewing information about anticonvulsants, a nursing student demonstrates understanding of this group of drugs, identifying which of the following as acting to elevate the seizure threshold by decreasing postsynaptic excitation?
Select all that apply.
A) Clonazepam (Klonopin)
B) Valproic acid (Depakote)
C) Gabapentin (Neurontin)
D) Lorazepam (Ativan)
E) Trimethadione (Tridione)
Ans: A, D
Feedback:
Benzodiazepines (clonazepam and lorazepam) exert their effect by elevating the seizure threshold by decreasing postsynaptic excitation. Valproic acid increases the levels of GABA, gabapentin is a GABA agonist, and trimethadione decreases the repetitive synaptic transmission of nerve impulses.
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