Outline and explain the cellular event that affects the force generated by smooth muscle cells. What are the initiating events, and how do these events affect force production by the smooth muscle cell? How can this process be activated without changes in membrane potential?
What will be an ideal response?
Describe how myosin light chain kinase and myosin light chain phosphatase are regulated as it is the interaction between two proteins that determines the extent of phosphorylation of the myosin light chain and thereby the amount of force generated by the smooth muscle cells. While responses in smooth muscle cells can be initiated by changes in membrane potential that increase intracellular calcium by altering calcium channel activity (electromechanical coupling) in the cell membrane, receptors that are activated by chemical signals can also stimulate the release of calcium from the sarcoplasmic reticulum without changes in membrane potential that can also affect force of contraction of smooth muscle cells (pharmacomechanical coupling).
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