Which of the following routes of medication administration demonstrates the least variability in drug response for pediatric clients of different ages?
a. oral c. intravenous
b. topical d. intramuscular
ANS: C
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A Incorrect: Children of different ages vary in gastric acidity, gastric emptying, and gastric absorption.
B Incorrect: Younger children have thinner skin and disproportionate skin surface area, resulting in variations in absorption.
C Correct: The intravenous route demonstrates the least variability, because regardless of the age the drug is injected directly into circulation.
D Incorrect: Because of the variation of sites used in different ages, the IM route has more variability in absorption than IV.
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