Monoclonal antibodies are used for a wide range of applications including serological assays and diagnostics probes in the laboratory, and as therapeutic reagents in the clinic
Discuss why ‘humanizing' monoclonal antibodies is necessary for use as therapeutic reagents but is not necessary when monoclonal antibodies are used as serological or diagnostic reagents.
What will be an ideal response?
Mice are used routinely to generate monoclonal antibodies. The constant regions of mouse antibodies are sufficiently different from the constant regions of human antibodies in amino acid composition that, if mouse antibodies are infused into a patient, an immune response will be stimulated and directed against the mouse constant-region epitopes. This immune response neutralizes the monoclonal antibody and in practice limits its intended use to one effective dose. When monoclonal antibodies are used for serological or diagnostic purposes in the laboratory, the monoclonal antibodies do not need to be humanized because laboratory assays are performed in vitro.
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What will be an ideal response?
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