The nurse is admitting to the unit a patient who has just had a minor operation and received a general anesthetic. The nurse notices that gentamicin (Garamycin) is infusing IV
Which of the following clinical findings associated with these drug-drug interactions would most alarm the nurse?
a. Diluted urine
b. Decreased sensation in the lower extremities
c. Hyperreflexia
d. Persistent headache
ANS: B
Neuromuscular blockade may occur after IV, intramuscular (IM), and oral administration of gentamicin. The risk of paralysis is increased by concurrent use of neuromuscular blocking agents and general anesthetics. Decreased sensation in the lower extremities may signal paralysis.
Diluted urine is not an effect of drug-drug interactions.
Hyperreflexia would not be anticipated, nor would persistent headache, which might be seen with ototoxicity related to concurrent administration of other ototoxic medications.
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