Which of the following mediators of inflammation is a biogenic amine stored in the cytoplasmic granules of mast cells, basophils, and platelets, causing increased permeability of venules in the tissue upon its release?
A. nitric oxide
B. prostaglandin E
C. platelet activating factor
D. interleukin (IL-1)
E. histamine
E
Histamine is a biogenic amine stored in the granules of mast cells, basophils, and platelets. Upon degranulation of these cells, it increases the permeability of venules, causing edema. All other mediators of inflammation listed here are not present in a prestored form and require time to be synthesized prior to release.
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