Why it is difficult to determine the administered dose of topical anesthetics drugs?

What will be an ideal response?


Unlike their injectable counterparts, maximum dose recommendations for many topical products do not exist. Even when manufacturers provide MRD information, clinicians often have difficulty determining how much was dispensed or absorbed. Compared to injectable administrations with calibrated cartridges containing specific concentrations of drugs, tracking topical dosages can be problematic. Patches and metered sprays offer more precise calculations as do some single-dose application systems. Liquids and gels in multiuse containers and nonmetered sprays present problems even if maximum doses are known because there is no easy way to determine how much was dispensed or how much was absorbed before being washed away in saliva.

Health Professions

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