Which of the following facts underlies the concept of replicative senescence?
A) Genes controlling longevity are present or absent in varying quantities among different individuals.
B) Telomeres become progressively shorter in successive generations of a cell.
C) The damaging influence of free radicals increases exponentially in later generations of a cell.
D) Aging produces mutations in DNA and deficits in DNA repair.
Ans: B
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Replicative senescence implies that cells have limited capacity for reproduction, largely as a result of the shortening of telomeres and consequent chromosomal damage. Genetic theories, the influence of free radicals, and DNA mutation are not central to the concept of replicative senescence.
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