What are the three lines of evidence that challenge fundamental aspects of many set-point theories of body-weight regulation?

What will be an ideal response?


(1) variability of body weight:
> a set-point mechanism should make it virtually impossibly for an adult to gain or lose large amounts of weight, yet many adults do!
> many people only avoid obesity by resisting those urges to eat

(2) set points and health:
> one implication of set-point theories is that each person's set point is optimal for that person's health, obviously not true
> free feeding levels of consumption are unhealthy
> all levels of dietary restriction substantially improved health and increased longevity, but the benefits were greatest in the mice whose caloric intake was reduced most

(3) regulation of body weight by changes in the efficiency of energy utilization:
> as a person's level of body fat declines, that person starts to use energy resources more efficiently, which limits further weight loss; conversely, weight gain is limited by a progressive decrease in the efficiency of energy utilization

Biology & Microbiology

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