While caring for a client who has just been diagnosed with leukocyte adhesion deficiency (LAD), the client asks why he is always sick with an infection

Question

The nurse responds, "LAD is a rare autosomal recessive disorder that results in recurrent infections because of the lack of transmigration. This means:
A) Your body doesn't make enough white blood cells."
B) Your white blood cells are not able to leave the blood vessels and move into the area of infection."
C) I don't really understand this, but it sounds like a good question to ask your physician."
D) Your bone marrow is damaged and can't put out enough white blood cells to fight off your infections."

Answer 1

Ans: B
Feedback:
Leukocyte adhesion deficiency (LAD) is a rare autosomal recessive disorder characterized by immunodeficiency, resulting in recurrent infections. A WBC differential will reveal extremely elevated levels of neutrophils (on the order of 6–10 times normal) because they are unable to leave the blood vessels. Certain integrins play an important role in allowing white blood cells to pass through the vessel wall, a process called transmigration.