In a discussion of drug-drug interactions, which would be the best example of a beneficial inhibitory interaction?
a. Naloxone (Narcan) blocking morphine sulfate's actions
b. Antacids blocking the action of tetracycline (Sumycin)
c. Alcohol blocking the actions of opioids
d. Cholestyramine blocking the actions of antihypertensive drugs
ANS: A
Naloxone is used when a narcotic overdose has occurred. As a narcotic antagonist, it provides a beneficial inhibitory interaction. An antacid blocking tetracycline's antibiotic effects would not be beneficial, but rather detrimental to the desired effects of the tetracycline. Alcohol would not block the effects of opiates, but would contribute to CNS depression. Cholestyramine and certain other adsorbent drugs, which are administered orally but do not undergo absorption, can adsorb other drugs onto themselves, thereby preventing absorption of the other drugs into the blood.
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