In a certain bacterial gene, transcription fails to initiate properly. What is a possible explanation?

a) DNA has not properly unwound from histones.
b) The is a mutation in the inverted repeat sequence so that a hairpin can not form.
c) There is a mutation at the Pribnow box at the -10 upstream location.
d) There is a mutation at the Pribnow box at the -35 upstream location.
e) TATA-binding protein (TBP) has not been added yet.


Ans: c) There is a mutation at the Pribnow box at the -10 upstream location.

Biology & Microbiology

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