Administering an aminoglycoside as monotherapy:
1. shortens the duration of therapy.
2. can lead to resistant bacterial strains.
3. reduces the incidence of adverse effects.
4. indicates that it is given intravenously.
Correct Answer: 2
Rationale 1: Monotherapy does not affect the duration of therapy.
Rationale 2: Monotherapy can lead to the development of resistant strains of bacteria.
Rationale 3: Monotherapy does not reduce the incidence of adverse effects.
Rationale 4: Bioavailability is associated with the route by which a drug is administered.
Global Rationale: Resistance develops quickly when aminoglycosides are administered as monotherapy. Resistance occurs when a species acquires an ability to degrade the antibiotic. Monotherapy does not shorten length of therapy and is not a strategy to reduce incidence of adverse effects. Monotherapy is not related to route of administration.
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