Which of the following statements most accurately describes the action of colestipol (Colestid) in the reduction of serum cholesterol levels?
a. It prevents synthesis of cholesterol by the liver.
b. It inhibits the secretion of cholesterol by the liver into bile salts.
c. It prevents the uptake of excess cholesterol from the blood stream by the liver.
d. It binds to bile salts in the gastrointestinal (GI) tract, preventing their reabsorp-tion.
ANS: D
Bile acid resins such as colestipol are anion-exchange resins that reduce low-density lipoprotein (LDL) levels by binding bile salts in exchange for chloride ions. These drugs form an insoluble complex with bile acids in the intestine. The bile acid-drug complex prevents the reabsorption of the bile acids, thus increasing their elimination. In an attempt to compensate for the loss of bile salts, the liver raises the rate of bile acid synthesis.
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