Which of the following will decrease oxygen's affinity for hemoglobin?
a. Increased CO2 c. Methemoglobin
b. Acute alkalosis d. Hypothermia
ANS: A
Increased CO2 causes acidosis, which decreases hemoglobin's affinity for oxygen. Acute alkalo-sis, methemoglobin, and hypothermia cause left shifts in the oxyhemoglobin dissociation curve.
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