Zidovudine (Retrovir) has been prescribed to a client with HIV. The client asks why blood needs to be drawn on a regular basis. What is the most appropriate response by the nurse?
1. "This medication can cause an increase in red and white blood cells, and needs to be monitored."
2. "This medication will cause dehydration, so your blood needs to be monitored for this."
3. "Serum creatinine must be monitored for clients taking zidovudine."
4. "Reduced numbers of red and white blood cells are common, and need to be monitored."
Correct Answer: 4
Rationale 1: "This medication can cause an increase in red and white blood cells, and needs to be monitored" is incorrect because it causes a decrease in red and white blood cells.
Rationale 2: "This medication will cause dehydration, so your blood needs to be monitored for this" is incorrect because it causes a decrease in red and white blood cells.
Rationale 3: "Serum creatinine must be monitored for clients taking zidovudine" is incorrect because it causes a decrease in red and white blood cells.
Rationale 4: Zidovudine can result in severe toxicity to blood cells at high doses. Reduced numbers of red blood cells (anemia) and white blood cells (leukopenia) are common, and can limit therapy.
Global Rationale: Zidovudine can result in severe toxicity to blood cells at high doses. Reduced numbers of red blood cells (anemia) and white blood cells (leukopenia) are common, and can limit therapy. "This medication can cause an increase in red and white blood cells, and needs to be monitored" is incorrect because it causes a decrease in red and white blood cells. "This medication will cause dehydration, so your blood needs to be monitored for this" is incorrect because it causes a decrease in red and white blood cells. "Serum creatinine must be monitored for clients taking zidovudine" is incorrect because it causes a decrease in red and white blood cells.
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