A nurse counsels a couple regarding their concerns about an X-linked disorder. Both parents are carriers of the disorder. They ask the nurse how this disorder will affect any children they might have. What is the nurse's best response?
1. "If you have a daughter, she will not be a carrier."
2. "If you have a daughter, she will not be affected."
3. "If you have a son, he will be a carrier."
4. "If you have a son, he will not be affected."
Correct Answer: 2
Rationale 1: Fathers affected with an X-linked disorder cannot pass the disorder to their sons, but all their daughters become carriers of the disorder.
Rationale 2: An X-linked disorder is manifested in a male who carries the abnormal gene on his only X chromosome.
Rationale 3: There is no male-to-male transmission of an X-linked disorder. An X-linked disorder is manifested in a male who carries the abnormal gene on his only X chromosome.
Rationale 4: There is a 50% chance that a carrier mother will pass the abnormal gene to each of her sons, who will thus be affected.
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