A 56-year-old woman has worked in a photography shop developing film for the past 20 years. She has a long history of shortness of breath and chronic cough, which have progressively become worse
Her FEV1 and FVC values were reduced but her FEV1/FVC ratio was within the normal range. Her diffusion capacity as measured by DLCO was low at 15 mL/min/mm Hg. A bronchoalveolar lavage and tissue biopsy were performed. The lavage sample revealed high numbers of macrophages but of abnormal appearance and high numbers of dead macrophages.
What type of pathology would you expect to find?
A. peribronchial inflammation with eosinophils
B. granulomatous-like lesion in the terminal bronchioles with interstitial fibrosis and large foamy macrophages
C. interstitial edema fluid accumulation with neutrophil infiltrate
D. emphysematous lesion with large alveoli and minimum interstitial fibrosis
ANS: B
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A. 0.9% NaCl B. 1.2% NaCl C. 0.5% NaCl