Which of the following pertains to the fate of immature B cells that have specificity for univalent self antigens? (Select all that apply.)
a. The cells acquire a state of unresponsiveness called anergy.
b. IgD is retained in the cytosol.
c. IgD on the cell surface fails to activate the B cell when bound to self antigen.
d. The cells have a much longer life-span than mature B cells.
e. The cells die by apoptosis.
A,C
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