The nurse is providing education to a client who was taking sibutramine (Meridia) as a part of a weight-loss program. The client asks the nurse why the medication was removed from the market. Which statement by the nurse is most appropriate?
1. "Sibutramine (Meridia) was removed from the market due to the adverse effects of postnasal drainage, pruritus, and drowsiness."
2. "Sibutramine (Meridia) was removed from the market due to the adverse effects of headache, constipation, and xerostomia."
3. "Sibutramine (Meridia) was removed from the market to the increased risk of heart attack and stroke."
4. "Sibutramine (Meridia) was removed from the market due to the increased risk for facial twitching, backache, and anxiety."
Correct Answer: 3
Rationale 1: Sibutramine (Meridia) does not cause postnasal drainage, pruritus, and drowsiness.
Rationale 2: Headache, constipation, and xerostomia are common adverse effects of sibutramine (Meridia) but they did not cause the medication to be removed from the market.
Rationale 3: Sibutramine (Meridia) was removed from the market in 2010 due to the increased risk of heart attack and stroke that were associated with the medication.
Rationale 4: Facial twitching, backache, and anxiety are not associated with sibutramine (Meridia).
Global Rationale: From 2007 until 2010, sibutramine (Meridia) was approved for the adjunctive treatment of obesity. The drug was able to produce a 5% to 10% loss of body weight within 6 to 12 months of treatment. Although well tolerated by most patients, sibutramine was found to produce an unacceptable incidence of serious cardiac events and stroke and was voluntarily removed from the market. It did not produce the other effects.
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