Researchers trying to determine the genetic basis of a rare inherited disease have been examining the pedigrees of eight families affected with the disease
For three of the families the disease is coinherited with markers on chromosome 2, but for the other five families the disease is coinherited with markers from chromosome 10 . Why might this discrepancy occur?
A. The same disease can be caused by defects in two or more genes on the same chromosome.
B. The gene product of chromosome 2 silences the defect on chromosome 10
C. The same disease can be caused by defects in two or more genes on different chromosomes.
D. Since more families showed linkage to chromosome 10, the disease gene is on chromosome 10 . The three families showing linkage to chromosome 2 are likely false positives.
C
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