If citrate levels are high in the cell, but ATP levels are low, what do you think will happen in the cell?
A. Glycolysis and the Krebs cycle will both be inhibited, thus under these conditions there will be no mechanism to generate ATP.
B. The electron transport chain will be inhibited, causing a build-up of NADH and FADH2. This will inhibit the Krebs cycle, but in the presence of glucose, glycolysis will still run coupled with fermentation to regenerate NAD+.
C. In the presence of glucose, glycolysis will run to generate energy for the cell, but the Krebs cycle will be inhibited.
D. Glycolysis will be inhibited, but the Krebs cycle will be functional, allowing it to be utilized to breakdown acetyl-CoA generated from beta-oxidation.
Answer: D
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