A client smokes regularly. She takes theophylline (Theo-Dur and others) daily. What is an effect of smoking while on theophylline?
a. Decrease in theophylline clearance
b. Increase in theophylline clearance
c. Increase in the distribution of theophylline
d. Decrease in the dose for theophylline
ANS: B
Smoking increases hepatic enzyme activity, increasing the clearance of theophylline (Theo-Dur and others). Smokers may need an increased dose of medication.
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