Which of the following statements about potential drug interactions with phenytoin is false?
A. Phenytoin increases theophylline clearance by increasing CYP 450 enzyme activity.
B. When taken with other highly protein-bound drugs, the free phenytoin concentration can increase to toxic levels.
C. Phenytoin can increase the metabolic capacity of hepatic enzymes, thus leading to reduced drug levels.
D. When phenytoin and theophylline are given together, the result is a higher concentration of both drugs than when given separately.
Answer: D. When phenytoin and theophylline are given together, the result is a higher concentration of both drugs than when given separately.
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