What is the fate of developing B cells that produce (i) functional or (ii) nonfunctional heavy and light chains?
What will be an ideal response?
At checkpoint 1, if the V(D)J rearrangement gives rise to a functional pre-B-cell receptor the late pro-B cell will be permitted to survive and undergo clonal proliferation. If V(D)J rearrangement produces a nonfunctional heavy chain and no pre-B-cell receptor is assembled, the pro-B cell undergoes apoptosis and dies. Similarly, at checkpoint 2, production of a functional light chain results in the assembly of a functional surface immunoglobulin and the survival and maturation of the B cell. Nonproduction of a light chain results eventually in apoptosis.
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