The primary health care provider has prescribed isoniazid (INH) for a client of Japanese descent diagnosed with tuberculosis. What factor must be considered in regard to the therapeutic effectiveness of this drug?
1. People of Japanese descent are known as rapid acetylators.
2. People of Japanese descent are usually allergic to isoniazid.
3. People of Japanese descent do not need medication to treat their tuberculosis.
4. People of Japanese descent are known as slow acetylators.
Correct Answer: 1
Rationale 1: Rapid acetylators inactivate the drug so quickly that it will not produce a therapeutic effect.
Rationale 2: There is no documented proof that clients of Japanese descent are any more or less allergic to isoniazid than any other ethnic group.
Rationale 3: All ethnic groups require medication to treat tuberculosis.
Rationale 4: People of Japanese descent are not slow acetylators.
Global Rationale: Rapid acetylators inactivate the drug so quickly that it will not produce a therapeutic effect. There is no documented proof that clients of Japanese descent are any more or less allergic to isoniazid than any other ethnic group. All ethnic groups require medication to treat tuberculosis. People of Japanese descent are not slow acetylators.
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