The potassium-sparing diuretic spironolactone (Aldactone) prolongs survival and improves heart failure symptoms by which mechanism?
a. Blocking aldosterone receptors
b. Increasing diuresis
c. Reducing venous pressure
d. Reducing afterload
ANS: A
Spironolactone prolongs survival in patients with HF primarily by blocking receptors for aldosterone. Spironolactone cause only minimal diuresis. Spironolactone does not reduce afterload, and it does not reduce venous pressure enough to prolong survival, because it causes only minimal diuresis.
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