The patient has been placed on deferoxamine (Deseral) therapy. Which adverse effect of the drug must the health care provider monitor closely for, to prevent death of the patient?
a. Red discoloration of the urine
b. Proliferation of specific organisms leading to infection
c. Ocular toxicity
d. Auditory neurotoxicity
ANS: B
Because deferoxamine is a naturally occurring iron siderophore (a molecule facilitating iron up-take), it acts as a growth factor for Yersinia and Rhizopus. In susceptible individuals, deferox-amine increases the proliferation and virulence of these organisms, resulting in severe, often fatal, infection.
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