The immune suppressive and anti-inflammatory effects of cortisol cause:
A) Moderate insulin resistance
B) Increased capillary permeability
C) Increased cell-mediated immunity
D) Inhibition of prostaglandin synthesis
Ans: D
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Large quantities of cortisol are required for an effective anti-inflammatory action. The increased cortisol blocks inflammation at an early stage by decreasing capillary permeability and stabilizing the lysosomal membranes so that inflammatory mediators are not released. Cortisol suppresses the immune response by reducing humoral and cell-mediated immunity. Cortisol also inhibits prostaglandin synthesis, which may account in large part for its anti-inflammatory actions. Cortisol stimulates glucose production by the liver; as glucose production by the liver rises and peripheral glucose use falls, a moderate resistance to insulin and hyperglycemia develop.
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