A patient is suffering from a condition requiring multiple blood transfusions. They have type A blood and their first transfusion was perfectly successful. However, their second transfusion of type A blood causes them to become very ill and observation of their blood reveals agglutination. What has happened to cause their second transfusion to fail?
A. They have developed a sensitivity to A antigens after being exposed to the first transfusion.
B. The second transfusion must have had anti-A antibodies, which began attacking their blood.
C. The blood used in the second transfusion must have come from a pregnant woman with Rh-negative blood.
D. The blood used in the first transfusion contained Rh antigens, which caused the patient to produce anti-Rh antibodies and attack the blood from the second transfusion.
Answer: D
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