Explain the JAK-STAT signaling pathway, and describe how it can contribute to disease
What will be an ideal response?
Answer: JAK: Janus family PTKs (protein tyrosine kinases) interact with the STAT transcription factors (signal transducers and activators of transcription). Once STAT proteins are phosphorylated by activated JAK kinases, they dimerize, translocate to the nucleus, bind to cytokine-specific DNA sequences, and activate (or inhibit) specific gene expression. Abnormalities in this pathway have been shown to cause polycythemia vera and other myeloproliferative disorders.
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Indicate whether the statement is true or false