A 70-year-old female client has had her mobility and independence significantly reduced by rheumatoid arthritis. Which of the following processes likely contributed to the development of her health problem?
A) Delayed-type hypersensitivity (DTH) reaction
B) Proliferation of cytotoxic T cells
C) Failure of normal self-tolerance
D) Deletion of autoreactive B cells
Ans: C
Feedback:
Ultimately, all autoimmune diseases are attributable to a disruption in self-tolerance that results in damage to body tissues by the immune system. Autoimmune diseases are not known to result from DTH reactions or the proliferation of cytotoxic T cells. Deletion of autoreactive B cells is a normal process that prevents autoimmune reactions in healthy individuals.
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