Males engrafted with HLA-identical bone marrow from their sisters develop graft-versus-host disease because _____
a. T cells develop in the male thymus that are not tolerant to minor histocompatibility antigens expressed by the sister
b. mature T cells in the graft have specificity for male-specific minor histocompatibility antigens
c. there are differences between the sexes in how self proteins are modified post-translationally
d. NK-cell alloreactions occur
e. residual female hormones in the graft cause upregulation of HLA class I on male dendritic cells presenting minor histocompatibility antigens.
B
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