A patient newly diagnosed with chronic myelocytic leukemia (`) has been prescribed treatment with imatinib. The patient asks the nurse how imatinib works. What would be the nurse's best response?
A) "imatinib alkylates cellular DNA."
B) "imatinib inhibits folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication."
C) "imatinib binds to DNA and inhibits DNA synthesis in susceptible cells, causing cell death."
D) "imatinib inhibits the enzyme created by the Philadelphia chromosome abnormality in CML."
D
Feedback:
Imatinib is a tyrosine kinase inhibitor that selectively inhibits the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality in CML and some tumor cells present in gastrointestinal stromal tumor (GIST); blocking this enzyme inhibits proliferation and induces cell division. Alkylating agents alkylate cellular DNA; antimetabolites inhibit folic acid reductase, leading to inhibition of deoxyribonucleic acid (DNA) synthesis and inhibition of cellular replication; and antineoplastic antibiotics bind to DNA and inhibit DNA synthesis in susceptible cells, causing cell death.
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A client with breast cancer has had genetic testing that shows she is a CYP2D6 ultra-rapid metabolizer. How would the nurse explain this result?
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A client is experiencing fatigue, shortness of breath, and tachycardia. Which deficiency should the nurse suspect in this client?
a. Iron b. Zinc c. Sodium d. Potassium
Medications ordered ac are to be given
A. before meals. B. after meals. C. with food. D. with milk.