The most frequent clinical signs of chronic Chagas disease involve the enlargement of which organ?
a. Heart
b. Liver
c. Spleen
d. Lung
A
Chronic Chagas disease may develop years after undetected infection or after the diagnosis of acute disease. Approximately 30% of patients may develop chronic Chagas disease, including cardiac changes and an enlargement of the colon and esophagus. Megacolon results in constipa-tion, abdominal pain, and the inability to discharge feces. An acute obstruction may lead to per-foration, septicemia, and death. However, the most frequent clinical signs of chronic Chagas disease involve the heart, in which enlargement of the heart and conduction changes are com-monly seen.
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a. altered target. b. increased efflux. c. decreased porin channels. d. degradative enzymes.
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A. because it is pumped by the heart. B. by entering large veins near the heart. C. by seeping into capillaries. D. when it enters arteries.