While explaining the physiology behind systemic sclerosis (scleroderma), the instructor states, "One of the hallmarks of scleroderma is:

Question

A) Activation of fibroblasts, resulting in fibrosis
B) The development of thin fragile skin
C) Development of a collagen deficiency
D) Avascular necrosis of the femoral head

Answer 1

Ans: A
Feedback:
Systemic sclerosis, sometimes called scleroderma, is an autoimmune disease of connective tissue characterized by excessive collagen deposition in the skin (with fibrotic thickening) and internal organs, such as the lungs, gastrointestinal tract, heart, and kidneys. Almost all persons with scleroderma develop polyarthritis and Raynaud phenomenon. Musculoskeletal manifestations of systemic lupus erythematosus (SLE), rather than systemic sclerosis, include rupture of the intrapatellar and Achilles tendons and avascular necrosis, frequently of the femoral head. RA granulomatous lesions have a central core of fibrinoid necrosis that is made up of a mixture of fibrin and other proteins such as degraded collagen.