Which statement(s) is/are true regarding the pharmacologic actions of certain antidepressant drugs? (Select all that apply.)
a. MAOIs block the effects of dopamine in the CNS.
b. SSRIs inhibit the destruction and reuptake of serotonin at the synaptic cleft.
c. Tricyclic antidepressants block the action of norepinephrine and epinephrine in the SNS.
d. Monocyclic antidepressants such as bupropion (Wellbutrin) have an unknown mechanism of action.
e. SNRIs prolong the action of neurotransmitters by decreasing the destruction of serotonin and norepinephrine.
ANS: B, D, E
SSRIs block the destruction and storage of serotonin at the synaptic cleft, therefore increasing the amount of serotonin available. Monocyclic antidepressants have an unknown mechanism of action. They are weaker inhibitors of the reuptake and inactivation of the neurotransmitters serotonin norepinephrine and dopamine. SNRIs act by inhibiting the reuptake and destruction of serotonin and norepinephrine and, to a lesser extent, dopamine, from the synaptic cleft, thereby prolonging the action of the neurotransmitters. MAOIs act by blocking the metabolic destruction of dopamine, so concentration is increased. Tricyclics block the reuptake of neurotransmitters, not their effects.
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