What is the fundamental defect that results in beta-thalassemia major?

a. The spleen prematurely destroys the precipitate-carrying cells.
b. A severe uncoupling of ?- and ?-chain synthesis occurs.
c. All four beta-forming genes are defective.
d. Hemoglobin H (HbH) develops when three genes are defective.


Answer: b. A severe uncoupling of ?- and ?-chain synthesis occurs.

Nursing

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A nurse leader, according to the American Organization of Nurse Executives (AOEN), is competent in the areas of (select all that apply):

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