What is a reason that aneuploidy in sex chromosomes is generally better tolerated than aneuploidy in autosomal chromosomes in humans?

A) In somatic cells, most of the genes on only one X chromosome are transcriptionally active.
B) Autosomal aneuploidy leads to heart defects and death in utero.
C) Y chromosome duplication results in only minor changes in testosterone levels.
D) Sex chromosome aneuploids may occur as the result of fertilization, but extra sex chromosomes are removed from the developing embryo during subsequent mitosis.
E) Any change in autosome number results in increased susceptibility to infection.


A) In somatic cells, most of the genes on only one X chromosome are transcriptionally active.

Biology & Microbiology

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