An African-American adult client is prescribed a sulfonamide drug to treat an infection. Why would the nurse question this prescribed medication order?
1. The client has a history of a penicillin allergy.
2. The client may exhibit slow acetylation which can impact the effect of the medication.
3. The client has a history of hypertension.
4. The client may not metabolize the medication due to CYP2D6.
Correct Answer: 2
Rationale 1: A penicillin allergy would not cause the nurse question this medication order.
Rationale 2: African-American clients may not be able to metabolize this mediation effectively because of the slow acetylation that is can occur when taking sulfa based medications. This can increase the risk of toxicity. The nurse should question this medication order.
Rationale 3: A history of hypertension would not cause the nurse to question this medication order.
Rationale 4: CYP2D6 does not impact sulfa medications and would not cause the nurse to question this medication order.
Global Rationale: African-American clients may not be able to metabolize this mediation effectively because of the slow acetylation that is can occur when taking sulfa based medications. This can increase the risk of toxicity. The nurse should question this medication order. A penicillin allergy would not cause the nurse question this medication order. A history of hypertension would not cause the nurse to question this medication order. CYP2D6 does not impact sulfa medications and would not cause the nurse to question this medication order.
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