A client with a diagnosis of schizophrenia has experienced a relapse after several months of improved symptom control. Which of the following factors should the care team consider when addressing the client's treatment resistance? (Select all that apply.)
A) The possibility of another psychiatric or medical diagnosis
B) The possibility of an allergic reaction
C) The plasma levels of the client's antipsychotic
D) Inherent biologic factors
E) The psychosocial treatment that the client is currently receiving
Ans: A, C, D, E
Over time, treatment resistance may occur due to several factors such as inherent biologic factors; inadequate dose or plasma level of the prescribed drug; missed diagnosis of a comorbid medical or psychiatric disorder; or inappropriate psychosocial treatment. Allergic reactions are a possibility with antipsychotic medications, but this would be unlikely after several months of treatment and would be unlikely to precipitate a relapse.
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