Which of the following is an implication of kidney changes in the older adult that the health care provider who is assessing drug response in this patient must take into consideration?
a. Drug half-life is lengthened.
b. Drug half-life is shortened.
c. Drug elimination is faster.
d. Toxic drug levels are less likely to occur.
ANS: A
Tubular secretory mechanisms and the ability to concentrate urine are diminished. In addition, cardiovascular disease, dehydration, and kidney disease commonly impair renal functioning. Thus the half-life of a drug may be increased by as much as 40%. Because drugs remain in the body longer, adverse and toxic effects are possible. Declines in renal function may be exagger-ated by comorbid illness such as chronic hypertension and anemia, which have close associations with chronic kidney disease.
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