Which of the following statements is correct in comparing metagenomic (next generation) sequencing to whole-genome (shotgun) sequencing?

A. Both sequencing methods have equal depth and coverage from the polymerase "reads" on the template.
B. Whole-genome sequencing does not fragment genomic sequences, but rather utilizes adaptor molecules on the template DNA.
C. Both sequencing methods utilize overlapping sequence contigs to assemble the full sequence.
D. Metagenomic sequencing uses a bacterial artificial chromosome (BAC) genomic library as the template.


Answer: C

Biology & Microbiology

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