Which of the following potential effects on pharmacokinetics results from the reduced gastric motility that occurs during pregnancy?
a. Reduced renal elimination
b. Unchanged drug distribution
c. Delayed drug absorption
d. Diminished drug biotransformation
ANS: C
The most fundamental change in the gastrointestinal tract during pregnancy is the increased ab-sorption of the nutrients needed by the developing fetus. Gastric motility and tone are decreased during pregnancy because of the smooth muscle relaxation effects of progesterone. These chang-es result in delayed gastric emptying, prolonged drug absorption, and lower peak drug concentra-tions.
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