A nurse monitors a client closely for methotrexate toxicity when the client is also prescribed which of the following? Select all that apply
A) Aspirin (Ecotrin)
B) Cephalexin (Keflex)
C) Sulfamethoxazole/trimethoprim (Septra)
D) Ibuprofen (Motrin)
E) Diclofenac (Voltaren)
Ans: A, C, D, E
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The nurse should closely monitor the client for methotrexate toxicity when methotrexates is given with aspirin (Ecotrin), sulfa antibiotics (Septra) and NSAIDs (ibuprofen and diclofenac).
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